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Disease Profile
TEMPI syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
Adult
ICD-10
-
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Telangiectasia Erythrocytosis Monoclonal gammopathy Perinephric-fluid collections Intrapulmonary shunting
Summary
TEMPI
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
100% of people have these symptoms | ||
Abnormality of the kidney |
Abnormal kidney
|
0000077 |
Hypoxemia |
Low blood oxygen level
|
0012418 |
Increased circulating IgG level | 0003237 | |
Increased hematocrit | 0001899 | |
Telangiectasia | 0001009 | |
80%-99% of people have these symptoms | ||
Abnormality of the pulmonary vasculature |
Abnormality of the lung blood vessels
|
0004930 |
Ascites |
Accumulation of fluid in the abdomen
|
0001541 |
Hemangioma |
Strawberry mark
|
0001028 |
Transudative pleural effusion | 0011920 | |
30%-79% of people have these symptoms | ||
Intracranial hemorrhage |
Bleeding within the skull
|
0002170 |
Polycythemia |
Increased red blood cells
|
0001901 |
Venous thrombosis |
Blood clot in vein
|
0004936 |
5%-29% of people have these symptoms | ||
Facial erythema |
Blushed cheeks
Blushing
Red face
Red in the face
[ more ] |
0001041 |
Headache |
Headaches
|
0002315 |
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss TEMPI syndrome. Click on the link to view a sample search on this topic.
References
- Sykes DB, Schroyens W, O'Connell C. The TEMPI syndrome--a novel multisystem disease. New England Journal of Medicine. August 3, 2011; 365(5):475-477. https://www.nejm.org/doi/full/10.1056/NEJMc1106670. Accessed 10/23/2012.
- Kwok M, Korde N, Landgren O. Bortezomib to Treat the TEMPI Syndrome. New England Journal of Medicine. May 10, 2012; 366(19):1843-1845. https://www.nejm.org/doi/full/10.1056/NEJMc1202649. Accessed 10/23/2012.
- Schroyens W, O'Connell C, Sykes DB. Complete and Partial Responses of the TEMPI Syndrome to Bortezomib. New England Journal of Medicine. August 23, 2012; 367(8):778-780. https://www.nejm.org/doi/full/10.1056/NEJMc1205806. Accessed 10/23/2012.