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Disease Profile
Mesangial proliferative glomerulonephritis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Glomerulonephritis mesangial proliferative; Mesangial proliferative GN; Mesangioproliferative glomerulonephritis
Summary
Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. Many experts consider it a variant of minimal change disease, but some experts believe it is a separate condition. It may present with nephrotic syndrome, which is a group of symptoms that include
Cause
Mesangial
In some cases, the underlying cause of MPGN is unclear.[3]
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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National Kidney Federation (NKF)
The Point
Shireoaks
Coach Road
Worksop
Notts S81 8BW
United Kingdom
Telephone: 0845 601 02 09
Website: https://www.kidney.org.uk/ -
NephCure Kidney International
150 S. Warner Road Suite 402
King of Prussia, PA 19406
Telephone: 1-866-NephCure (637-4287)
E-mail: [email protected]
Website: https://nephcure.org/
Organizations Providing General Support
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American Association of Kidney Patients
3505 E. Frontage Rd., Suite 315
Tampa, FL 33607-1796
Toll-free: 800-749-2257
Telephone: 813-636-8100
Fax: 813-636-8122
E-mail: [email protected]
Website: https://www.aakp.org -
American Kidney Fund (AKF)
11921 Rockville Pike
Suite 300
Rockville, MD 20852
Toll-free: 866-300-2900
E-mail: [email protected]
Website: https://www.kidneyfund.org -
National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Toll-free: 800-622-9010
Telephone: 212-889-2210
Fax: 212-689-9261
E-mail: [email protected]
Website: https://www.kidney.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
References
- Meyrier, A and Appel GB. Minimal change variants: Mesangial proliferation; IgM nephropathy; C1q nephropathy. UpToDate. Waltham, MA: UpToDate; January, 2016; https://www.uptodate.com/contents/minimal-change-variants-mesangial-proliferation-igm-nephropathy-c1q-nephropathy.
- Mokhtar GA, Jalalah S, Sultana S. Pathological patterns of mesangioproliferative glomerulonephritis seen at a tertiary care center. J Nephropharmacol. July 1, 2014; 3(2):33-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297525/.
- Zhao JJ, Wang XB, Luan Y, Liu JL, Liu L, Jia HY. Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. Biomed Rep. September, 2013; 1(5):751-756. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917055/.
- Salifu MO. Diffuse Proliferative Glomerulonephritis. Medscape Reference. April 28, 2015; https://emedicine.medscape.com/article/239646-overview.
- IgA Nephropathy. NIDDK. November, 2015; https://www.niddk.nih.gov/health-information/kidney-disease/iga-nephropathy.
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