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Disease Profile
Median arcuate ligament syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
MALS; Celiac artery compression syndrome; Celiac axis syndrome;
Summary
Median arcuate ligament
Symptoms
One review found that abdominal pain is the most common symptom, found to be present in approximately 80% of individuals, while weight loss was found in approximately 48% and abdominal bruit was appreciated in approximately 35%.[4]
Other symptoms include: nausea, diarrhea, vomiting, and delayed gastric emptying.[1][2]
Cause
Diagnosis
Treatment
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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National MALS Foundation
P.O. Box 1292
Dedham, MA 02027
E-mail: https://www.malsfoundation.org/contact-us
Website: https://www.malsfoundation.org/
Social Networking Websites
- MALS Pals is a closed Facebook group for Median arcuate ligament syndrome
- Visit the MALS Awareness group on Facebook.
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- The The Cleveland Clinic Web site has an information page on Median arcuate ligament syndrome. Click on the Cleveland Clinic link to view this page.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Median arcuate ligament syndrome. Click on the link to view a sample search on this topic.
References
- Scovell S and Hamdan A. Celiac artery compression syndrome. UpToDate. June 1 2016; https://www.uptodate.com/contents/celiac-artery-compression-syndrome.
- Allison J. Porter, Robert B. Yates, Joshua M. Mourot, Brant K. Oelschlager. A Compressed Celiac Artery May Lead to High-Risk Surgery. Medscape. September 11, 2015; https://www.medscape.com/viewarticle/847153.
- Celiac Artery Compression Syndrome. Baylor College of Medicine. https://www.bcm.edu/healthcare/care-centers/vascular-surgery/conditions/celiac-artery-compression-syndrome.
- Juan Carlos Jimenez, Michael Harlander-Locke, Erik P. Dutson, MD. Open and laparoscopic treatment of median arcuate ligament syndrome. Journal of Vascular Surgery. September 2012; 56(3):869-873. https://www.ncbi.nlm.nih.gov/pubmed/22743019.
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