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Disease Profile
Juvenile idiopathic arthritis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
#N/A
Age of onset
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ICD-10
#N/A
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Juvenile rheumatoid arthritis; Arthritis, juvenile rheumatoid; Juvenile chronic arthritis;
Summary
Juvenile idiopathic
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Arthralgia |
Joint pain
|
0002829 |
Arthritis |
Joint inflammation
|
0001369 |
Autoimmunity |
Autoimmune disease
Autoimmune disorder
[ more ] |
0002960 |
Fever | 0001945 | |
30%-79% of people have these symptoms | ||
Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
Abnormal fingernail morphology |
Abnormal fingernails
Abnormality of the fingernails
[ more ] |
0001231 |
Abnormal pleura morphology | 0002103 | |
Abnormality of the sacroiliac joint | 0100781 | |
Cartilage destruction | 0100773 | |
Generalized hyperkeratosis | 0005595 | |
Joint dislocation |
Joint dislocations
Recurrent joint dislocations
[ more ] |
0001373 |
Joint stiffness |
Stiff joint
Stiff joints
[ more ] |
0001387 |
Joint swelling | 0001386 | |
Malabsorption |
Intestinal malabsorption
|
0002024 |
Mediastinal lymphadenopathy |
Swollen lymph nodes in center of chest
|
0100721 |
Nail pits |
Nail pitting
Pitted nails
[ more ] |
0001803 |
Psoriasiform dermatitis | 0003765 | |
Skin rash | 0000988 | |
Uveitis | 0000554 | |
5%-29% of people have these symptoms | ||
Hepatomegaly |
Enlarged liver
|
0002240 |
Pericardial effusion |
Fluid around heart
|
0001698 |
Splenomegaly |
Increased spleen size
|
0001744 |
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Tocilizumab(Brand name: Actemra) Manufactured by Genentech, Inc
FDA-approved indication: May 2018, tocilizumab (Actemra) received expanded approval for treatment of pediatric patients (age 16 years and younger) with polyarticular-course juvenile idiopathicarthritis .
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Etanercept(Brand name: Enbrel®) Manufactured by Amgen
FDA-approved indication: Reduction in signs and symptoms of moderately to severely active polyarticular-course juvenile rheumatoid arthritis in patients who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Adalimumab(Brand name: Humira) Manufactured by AbbVie Inc.
FDA-approved indication: Treatment of Juvenile Idiopathic Arthritis. Reducing signs and symptoms and inducing and maintaining clinicalremission in patients 6 years of age and older with moderately to severely active Crohn's disease who have had an inadequate response tocorticosteroids or immunomodulators such as azathioprine, 6-mercaptopurine, or methotrexate.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Canakinumab(Brand name: Ilaris) Manufactured by Novartis Pharmaceuticals Corporation
FDA-approved indication: June 2009, canakinumab (Ilaris) was approved for the treatment of cryopyrin-associated periodicsyndromes (CAPS), in adults and children 4 years of age and older. In May 2013, it was also approved for the treatment of active Systemic Juvenile Idiopathic Arthritis (SJIA) in patients aged 2 through 16 years.
National Library of Medicine Drug Information Portal - Meloxicam(Brand name: Mobic) Manufactured by Boehringer Ingelheim Pharmaceuticals, Inc.
FDA-approved indication: For relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis in patients 2 years of age or older.
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
Arthritis Foundation
1355 Peachtree St. NE
6th Floor
Atlanta, GA 30309
Toll-free: 1-844-571-HELP (4357)
Telephone: +1-404-872-7100
Website: https://www.arthritis.org -
Canadian Spondylitis Association (CSA)
Canada
Telephone: +1-705-715-2162
E-mail: [email protected]
Website: https://www.spondylitis.ca -
Juvenile Arthritis Association
8549 Wilshire Blvd. Suite #103
Beverly Hills, CA 90211
E-mail: [email protected]
Website: https://www.facebook.com/juvenilearthritis/ -
The Arthritis Society
393 University Avenue, Suite 1700
Toronto, Ontario M5G 1E6
Canada
Toll-free: 1-800-321-1433
Telephone: +1-416-979-7228
Fax: +1-416-979-8366
E-mail: [email protected]
Website: https://arthritis.ca/
Organizations Providing General Support
-
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
Toll-free: 800-598-4668
Telephone: 586-776-3900
Fax: 586-776-3903
E-mail: [email protected]
Website: https://www.aarda.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- Genetics Home Reference (GHR) contains information on Juvenile idiopathic arthritis. This website is maintained by the National Library of Medicine.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
In-Depth Information
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Juvenile idiopathic arthritis. Click on the link to view a sample search on this topic.
References
- Questions and Answers about Juvenile Arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases; June 2015; https://www.niams.nih.gov/Health_info/Juv_Arthritis/.